:root {
  --primary-color: #007b41;
  --secondary-color: #005c30;
  --background-color: #f8fafc;
  --surface-color: #ffffff;
  --text-primary: #1e293b;
  --text-secondary: #64748b;
  --border-color: #e2e8f0;
  --success-color: #007b41;
  --warning-color: #f59e0b;
  --error-color: #ef4444;
  --gradient-bg: linear-gradient(135deg, #007b41 0%, #009a52 100%);
  --box-shadow: 0 4px 6px -1px rgba(0,0,0,0.1), 0 2px 4px -1px rgba(0,0,0,0.06);
}

* { margin: 0; padding: 0; box-sizing: border-box; }

body {
  font-family: Verdana, Geneva, Tahoma, sans-serif;
  background-color: var(--background-color);
  color: var(--text-primary);
  line-height: 1.6;
}

a { color: var(--primary-color); text-decoration: none; }
a:hover { text-decoration: underline; }

.container { max-width: 1400px; margin: 0 auto; padding: 0 20px; }

/* ========== Navigation ========== */
.navbar {
  background: var(--gradient-bg);
  padding: 0;
  position: sticky;
  top: 0;
  z-index: 100;
  box-shadow: 0 2px 8px rgba(0,0,0,0.15);
}

.nav-container {
  max-width: 1400px;
  margin: 0 auto;
  padding: 0 20px;
  display: flex;
  align-items: center;
  justify-content: space-between;
  height: 56px;
}

.nav-logo {
  color: #fff;
  font-size: 1.4rem;
  font-weight: 700;
  letter-spacing: 1px;
}
.nav-logo:hover { text-decoration: none; opacity: 0.9; }

.nav-toggle {
  display: none;
  background: none;
  border: none;
  color: #fff;
  font-size: 1.5rem;
  cursor: pointer;
}

.nav-links {
  list-style: none;
  display: flex;
  gap: 4px;
}

.nav-links a {
  color: rgba(255,255,255,0.85);
  padding: 8px 16px;
  font-size: 14px;
  font-weight: 600;
  transition: all 0.2s;
}
.nav-links a:hover, .nav-links a.active {
  color: #fff;
  background: rgba(255,255,255,0.15);
  text-decoration: none;
}

/* ========== Hero Section ========== */
.hero {
  background: var(--gradient-bg);
  padding: 60px 20px 50px;
  text-align: center;
  color: #fff;
}

.hero h1 {
  font-size: 3rem;
  font-weight: 700;
  margin-bottom: 12px;
  letter-spacing: 2px;
}

.hero-subtitle {
  font-size: 1.1rem;
  opacity: 0.95;
  margin-bottom: 8px;
}

.hero-desc {
  font-size: 0.95rem;
  opacity: 0.8;
  margin-bottom: 30px;
  max-width: 700px;
  margin-left: auto;
  margin-right: auto;
}

.hero-search {
  display: flex;
  gap: 10px;
  max-width: 700px;
  margin: 0 auto;
}

.hero-search-input {
  flex: 1;
  padding: 14px 18px;
  border: none;
  font-size: 14px;
  background: #fff;
  color: var(--text-primary);
}

.hero-search-btn {
  padding: 14px 24px;
  border: none;
  background: var(--secondary-color);
  color: #fff;
  font-size: 14px;
  font-weight: 600;
  cursor: pointer;
  transition: background 0.2s;
}
.hero-search-btn:hover { background: #004a27; }

/* ========== Sections ========== */
.section {
  margin: 40px 0;
}

.section-title {
  font-size: 1.6rem;
  color: var(--text-primary);
  margin-bottom: 8px;
  position: relative;
  padding-bottom: 10px;
}
.section-title::after {
  content: '';
  position: absolute;
  bottom: 0;
  left: 0;
  width: 60px;
  height: 3px;
  background: var(--primary-color);
}

.section-desc {
  color: var(--text-secondary);
  margin-bottom: 24px;
  margin-top: 12px;
}

.species-search-bar {
  display: flex;
  gap: 10px;
  align-items: center;
  max-width: 420px;
  margin-bottom: 12px;
}

.species-search-input {
  flex: 1;
  min-width: 0;
  padding: 10px 14px;
  border: 1px solid var(--border-color);
  background: var(--surface-color);
  color: var(--text-primary);
  font-size: 14px;
}

.species-search-input:focus {
  outline: 2px solid rgba(0, 123, 65, 0.18);
  border-color: var(--primary-color);
}

.species-search-clear {
  padding: 10px 14px;
  border: 1px solid var(--border-color);
  background: var(--surface-color);
  color: var(--text-primary);
  font-size: 13px;
  font-weight: 600;
  cursor: pointer;
}

.species-search-clear:hover {
  background: #f1f5f9;
}

.species-search-status {
  margin-bottom: 18px;
  color: var(--text-secondary);
  font-size: 0.9rem;
}

/* ========== Species Grid ========== */
.species-grid {
  display: grid;
  grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
  gap: 24px;
}

.species-card {
  background: var(--surface-color);
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
  transition: transform 0.2s, box-shadow 0.2s;
  display: block;
  color: var(--text-primary);
  overflow: hidden;
}
.species-card:hover {
  transform: translateY(-4px);
  box-shadow: 0 8px 20px rgba(0,0,0,0.12);
  text-decoration: none;
}

.species-card-header {
  background: var(--gradient-bg);
  padding: 16px 20px;
  display: flex;
  justify-content: space-between;
  align-items: center;
}

.species-abbr {
  color: #fff;
  font-size: 1.3rem;
  font-weight: 700;
  letter-spacing: 1px;
}

.species-card-body { padding: 20px; }

.species-name {
  font-size: 1.1rem;
  font-style: italic;
  margin-bottom: 4px;
}

.species-common {
  color: var(--text-secondary);
  font-size: 0.9rem;
  margin-bottom: 16px;
}

.species-stats {
  display: flex;
  gap: 16px;
  border-top: 1px solid var(--border-color);
  padding-top: 14px;
}

.species-stat { text-align: center; flex: 1; }

.species-stat-num {
  display: block;
  font-size: 1.1rem;
  font-weight: 700;
  color: var(--primary-color);
}

.species-stat-label {
  font-size: 0.75rem;
  color: var(--text-secondary);
  text-transform: uppercase;
}

/* ========== Overview Stats ========== */
.overview-stats {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: 20px;
}

.overview-card {
  background: var(--surface-color);
  padding: 28px;
  text-align: center;
  box-shadow: var(--box-shadow);
  border: 1px solid var(--border-color);
}

.overview-number {
  font-size: 2.2rem;
  font-weight: 700;
  color: var(--primary-color);
  margin-bottom: 6px;
}

.overview-label {
  color: var(--text-secondary);
  font-weight: 500;
  font-size: 0.95rem;
}

/* ========== Feature Cards ========== */
.about-content {
  background: var(--surface-color);
  padding: 30px;
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
}
.about-content > p { margin-bottom: 24px; }

.feature-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(240px, 1fr));
  gap: 20px;
}

.feature-card {
  background: var(--background-color);
  padding: 24px;
  border: 1px solid var(--border-color);
  text-align: center;
}

.feature-icon { font-size: 2rem; margin-bottom: 10px; }
.feature-card h3 { color: var(--primary-color); margin-bottom: 8px; font-size: 1rem; }
.feature-card p { font-size: 0.85rem; color: var(--text-secondary); }

/* ========== Species Page Header ========== */
.species-header-banner {
  background: var(--gradient-bg);
  padding: 30px 0;
  color: #fff;
}

.species-header-banner h1 {
  font-size: 2rem;
  margin-bottom: 6px;
  text-align: center;
}

.species-header-banner > .container > p {
  text-align: center;
  opacity: 0.85;
  margin-bottom: 18px;
}

.search-container {
  display: flex;
  gap: 10px;
  max-width: 720px;
  margin: 0 auto;
  position: relative;
}

.search-input {
  flex: 1;
  padding: 12px 16px;
  border: 1px solid var(--border-color);
  font-size: 14px;
  background: #fff;
  color: var(--text-primary);
}

.search-btn, .clear-btn {
  padding: 12px 18px;
  border: none;
  font-size: 14px;
  font-weight: 600;
  cursor: pointer;
  transition: all 0.2s;
}
.search-btn { background-color: var(--secondary-color); color: #fff; }
.search-btn:hover { background-color: #004a27; }
.clear-btn { background-color: var(--error-color); color: #fff; }
.clear-btn:hover { background-color: #dc2626; }

.search-suggestions {
  position: absolute;
  top: 100%;
  left: 0;
  right: 120px;
  background: #fff;
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
  z-index: 50;
  display: none;
  max-height: 200px;
  overflow-y: auto;
}

.search-suggestions .suggestion-item {
  padding: 8px 16px;
  cursor: pointer;
  font-size: 14px;
  color: var(--text-primary);
}
.search-suggestions .suggestion-item:hover {
  background-color: #f1f5f9;
}

/* ========== Stats Cards ========== */
.stats-section { margin: 30px 0; }

.stats-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: 20px;
}

.stat-card {
  background: var(--surface-color);
  padding: 22px;
  text-align: center;
  box-shadow: var(--box-shadow);
  border: 1px solid var(--border-color);
}

.stat-number {
  font-size: 2rem;
  font-weight: 700;
  color: var(--primary-color);
  margin-bottom: 6px;
}

.stat-label {
  color: var(--text-secondary);
  font-weight: 500;
}

/* ========== Filter Section ========== */
.filter-section {
  background: var(--surface-color);
  padding: 20px;
  margin-bottom: 30px;
  box-shadow: var(--box-shadow);
  border: 1px solid var(--border-color);
}

.filter-controls {
  display: flex;
  gap: 20px;
  align-items: center;
  flex-wrap: wrap;
}

.filter-controls label {
  display: flex;
  align-items: center;
  gap: 8px;
  font-weight: 500;
}

.filter-controls select, .filter-controls input {
  padding: 8px 10px;
  border: 1px solid var(--border-color);
  font-size: 14px;
}

.filter-btn {
  padding: 8px 14px;
  background-color: var(--secondary-color);
  color: #fff;
  border: none;
  cursor: pointer;
  font-weight: 600;
}
.filter-btn:hover { background-color: #004a27; }

/* ========== Results Table ========== */
.results-section {
  background: var(--surface-color);
  padding: 22px;
  box-shadow: var(--box-shadow);
  border: 1px solid var(--border-color);
  margin-bottom: 30px;
}

.results-section h2 {
  color: var(--text-primary);
  margin-bottom: 16px;
  font-size: 1.3rem;
}

.result-count {
  font-size: 0.9rem;
  font-weight: 400;
  color: var(--text-secondary);
}

.table-container { overflow-x: auto; margin-bottom: 16px; }

.results-table { width: 100%; border-collapse: collapse; font-size: 14px; }

.results-table th {
  background: var(--primary-color);
  color: #fff;
  padding: 12px 10px;
  font-weight: 700;
  text-align: left;
  position: sticky;
  top: 0;
  cursor: pointer;
  user-select: none;
  white-space: nowrap;
}
.results-table th:hover { background: #006837; }

.results-table td { padding: 10px; border-bottom: 1px solid var(--border-color); }
.results-table tr:hover { background-color: #f1f5f9; }

.protein-link {
  color: var(--primary-color);
  text-decoration: none;
  font-weight: 600;
  cursor: pointer;
}
.protein-link:hover { text-decoration: underline; }

.probability-cell { font-weight: 700; }

.prediction-positive {
  background-color: #dcfce7;
  color: #166534;
  padding: 3px 6px;
  font-weight: 700;
}

.prediction-negative {
  background-color: #fee2e2;
  color: #991b1b;
  padding: 3px 6px;
  font-weight: 700;
}

.interpretability-btn {
  padding: 6px 10px;
  background-color: var(--primary-color);
  color: #fff;
  border: none;
  cursor: pointer;
  font-size: 12px;
  font-weight: 700;
}
.interpretability-btn:hover { background-color: #006837; }
.interpretability-btn:disabled { background-color: var(--text-secondary); cursor: not-allowed; }

.loading-cell { text-align: center; padding: 40px; color: var(--text-secondary); }

/* ========== Pagination ========== */
.pagination {
  display: flex;
  align-items: center;
  justify-content: center;
  gap: 12px;
  margin-top: 14px;
}

.page-btn {
  padding: 8px 14px;
  background-color: var(--primary-color);
  color: #fff;
  border: none;
  cursor: pointer;
  font-weight: 700;
}
.page-btn:hover:not(:disabled) { background-color: #006837; }
.page-btn:disabled { background-color: var(--text-secondary); cursor: not-allowed; }

/* ========== Modal ========== */
.modal {
  display: none;
  position: fixed;
  z-index: 1000;
  left: 0;
  top: 0;
  width: 100%;
  height: 100%;
  background-color: rgba(0,0,0,0.5);
}

.modal-content {
  background-color: var(--surface-color);
  margin: 3% auto;
  border-radius: 0;
  width: 90%;
  max-width: 900px;
  max-height: 90vh;
  overflow: hidden;
  box-shadow: 0 25px 50px -12px rgba(0,0,0,0.25);
  display: flex;
  flex-direction: column;
}

.modal-wide { max-width: 1100px; }

.modal-header {
  background: var(--primary-color);
  color: #fff;
  padding: 16px 22px;
  display: flex;
  justify-content: space-between;
  align-items: center;
  flex-shrink: 0;
}

.modal-header h3 { font-size: 1.2rem; }

.close { font-size: 24px; font-weight: bold; cursor: pointer; color: #fff; }
.close:hover { color: #f1f5f9; }

.modal-body {
  padding: 22px;
  overflow-y: auto;
  flex: 1;
}

/* ========== Sequence Viewer ========== */
.sequence-viewer {
  background: #f8fafc;
  border: 1px solid var(--border-color);
  padding: 16px;
  margin: 12px 0;
}

.sequence-header {
  display: flex;
  justify-content: space-between;
  align-items: center;
  margin-bottom: 10px;
}

.sequence-title { font-weight: 700; color: var(--text-primary); }
.sequence-length { color: var(--text-secondary); font-size: 12px; }

.sequence-display-fasta {
  font-family: 'Monaco','Menlo','Ubuntu Mono','Courier New',monospace;
  font-size: 14px;
  line-height: 1.6;
  background: #fff;
  padding: 12px;
  border: 1px solid var(--border-color);
  max-height: 400px;
  overflow-y: auto;
  user-select: text;
}

.sequence-position-header {
  color: var(--text-secondary);
  font-size: 10px;
  margin-bottom: 2px;
  font-family: 'Monaco','Menlo','Ubuntu Mono','Courier New',monospace;
  display: flex;
  white-space: nowrap;
  user-select: none;
  -webkit-user-select: none;
}

.position-marker {
  display: inline-block;
  width: 10px;
  text-align: center;
  color: var(--text-secondary);
  font-size: 9px;
  font-family: 'Monaco','Menlo','Ubuntu Mono','Courier New',monospace;
  user-select: none;
  -webkit-user-select: none;
}

.position-marker[data-pos]::after {
  content: attr(data-pos);
}

.attention-residue-fasta {
  display: inline-block;
  width: 10px;
  text-align: center;
  cursor: pointer;
  font-weight: bold;
  letter-spacing: 0;
  font-family: 'Monaco','Menlo','Ubuntu Mono','Courier New',monospace;
  background-color: transparent;
}
.attention-residue-fasta:hover { opacity: 0.7; }

.sequence-spacer { display: inline-block; width: 50px; }
.sequence-fasta-line { white-space: nowrap; }

/* ========== Attention Controls ========== */
.attention-controls {
  display: flex;
  gap: 16px;
  align-items: center;
  margin: 10px 0;
  padding: 10px;
  background: #f8fafc;
  border: 1px solid var(--border-color);
  flex-wrap: wrap;
}

.attention-controls label {
  display: flex;
  align-items: center;
  gap: 6px;
  font-weight: 600;
  color: var(--text-primary);
}

.attention-controls input, .attention-controls select {
  padding: 6px 8px;
  border: 1px solid var(--border-color);
  font-size: 14px;
}

.attention-legend {
  display: flex;
  align-items: center;
  gap: 8px;
  margin: 10px 0;
  padding: 8px 10px;
  background: #fff;
  border: 1px solid var(--border-color);
}

.legend-label-low, .legend-label-high {
  font-size: 12px;
  color: var(--text-secondary);
  font-weight: 600;
  white-space: nowrap;
}

.legend-gradient {
  width: 200px;
  height: 20px;
  border: 1px solid #ccc;
  flex-shrink: 0;
}

.legend-labels {
  display: flex;
  justify-content: space-between;
  width: 200px;
  font-size: 12px;
  color: var(--text-secondary);
}

/* ========== CIS table in modal ========== */
.cis-table { width: 100%; border-collapse: collapse; margin-top: 12px; font-size: 14px; }
.cis-table th { background: var(--primary-color); color: #fff; padding: 10px 8px; text-align: left; font-weight: 700; }
.cis-table td { padding: 9px 8px; border-bottom: 1px solid var(--border-color); }
.cis-table tr:hover { background-color: #f8fafc; }

/* ========== Downloads ========== */
.downloads-section {
  background: var(--surface-color);
  padding: 22px;
  box-shadow: var(--box-shadow);
  border: 1px solid var(--border-color);
  margin-bottom: 30px;
}

.download-item {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 12px;
  border-bottom: 1px solid var(--border-color);
}

.download-item:last-child { border-bottom: none; }

.download-btn {
  padding: 6px 14px;
  background: var(--primary-color);
  color: #fff;
  border: none;
  font-weight: 600;
  cursor: pointer;
  text-decoration: none;
  font-size: 13px;
}
.download-btn:hover { background: #006837; text-decoration: none; }

/* ========== Page Header (citation, contact, help) ========== */
.page-header {
  background: var(--gradient-bg);
  padding: 40px 0;
  color: #fff;
  text-align: center;
}
.page-header h1 { font-size: 2rem; margin-bottom: 8px; }
.page-header p { opacity: 0.85; }

/* ========== Citation ========== */
.citation-card {
  background: var(--surface-color);
  padding: 30px;
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
}
.citation-card h3 { color: var(--primary-color); margin-bottom: 12px; }
.citation-authors { font-weight: 500; margin-bottom: 4px; }
.citation-journal { color: var(--text-secondary); font-style: italic; margin-bottom: 20px; }

.citation-box {
  background: #f8fafc;
  padding: 16px;
  border: 1px solid var(--border-color);
  margin-top: 16px;
}
.citation-box h4 { margin-bottom: 8px; color: var(--text-primary); }

.citation-bibtex {
  font-family: 'Courier New', monospace;
  font-size: 13px;
  white-space: pre-wrap;
  background: #fff;
  padding: 12px;
  border: 1px solid var(--border-color);
  margin-bottom: 12px;
  overflow-x: auto;
}

.copy-btn {
  padding: 8px 16px;
  background: var(--primary-color);
  color: #fff;
  border: none;
  cursor: pointer;
  font-weight: 600;
}
.copy-btn:hover { background: #006837; }

.resource-list { list-style: none; }
.resource-list li {
  padding: 12px 0;
  border-bottom: 1px solid var(--border-color);
  line-height: 1.7;
}

/* ========== Contact ========== */
.contact-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
  gap: 24px;
}

.contact-card {
  background: var(--surface-color);
  padding: 24px;
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
}
.contact-card h3 { color: var(--primary-color); margin-bottom: 12px; }
.contact-card p { margin-bottom: 6px; }

/* ========== Help ========== */
.help-content {
  background: var(--surface-color);
  padding: 30px;
  border: 1px solid var(--border-color);
  box-shadow: var(--box-shadow);
}

.help-item { margin-bottom: 28px; }
.help-item:last-child { margin-bottom: 0; }
.help-item h3 { color: var(--primary-color); margin-bottom: 8px; }
.help-item ul { padding-left: 20px; margin-top: 6px; }
.help-item li { margin-bottom: 4px; }
.help-item code {
  background: #f1f5f9;
  padding: 2px 6px;
  font-size: 13px;
  border: 1px solid var(--border-color);
}

.help-table { width: 100%; border-collapse: collapse; margin-top: 8px; }
.help-table th, .help-table td { padding: 10px 12px; text-align: left; border-bottom: 1px solid var(--border-color); }
.help-table th { background: var(--background-color); font-weight: 600; }

/* ========== Footer ========== */
.footer {
  background: #1e293b;
  color: rgba(255,255,255,0.7);
  padding: 40px 0 20px;
  margin-top: 60px;
}

.footer-container { max-width: 1400px; margin: 0 auto; padding: 0 20px; }

.footer-content {
  display: grid;
  grid-template-columns: 2fr 1fr;
  gap: 40px;
  margin-bottom: 30px;
}

.footer-section h4 { color: #fff; margin-bottom: 12px; font-size: 1rem; }
.footer-section p { font-size: 0.85rem; line-height: 1.7; }
.footer-section ul { list-style: none; }
.footer-section ul li { margin-bottom: 6px; }
.footer-section ul a { color: rgba(255,255,255,0.7); font-size: 0.85rem; }
.footer-section ul a:hover { color: #fff; text-decoration: none; }

.footer-bottom {
  border-top: 1px solid rgba(255,255,255,0.1);
  padding-top: 20px;
  text-align: center;
  font-size: 0.8rem;
}

/* ========== Utility ========== */
.loading { text-align: center; padding: 40px; color: var(--text-secondary); }
.error { text-align: center; padding: 40px; color: var(--error-color); }
.empty-state { text-align: center; padding: 40px; color: var(--text-secondary); font-style: italic; }

/* ========== Responsive ========== */
@media (max-width: 768px) {
  .nav-toggle { display: block; }

  .nav-links {
    display: none;
    flex-direction: column;
    position: absolute;
    top: 56px;
    left: 0;
    right: 0;
    background: var(--secondary-color);
    padding: 10px 0;
  }
  .nav-links.show { display: flex; }
  .nav-links a { padding: 12px 20px; }

  .hero h1 { font-size: 2rem; }
  .hero-search { flex-direction: column; }
  .species-search-bar { max-width: 100%; }

  .species-grid { grid-template-columns: 1fr; }
  .stats-grid { grid-template-columns: repeat(2, 1fr); }
  .filter-controls { flex-direction: column; align-items: stretch; }
  .results-table { font-size: 12px; }
  .modal-content { width: 98%; margin: 2% auto; }

  .footer-content { grid-template-columns: 1fr; gap: 20px; }

  .search-container { flex-direction: column; }
  .species-search-bar { flex-direction: column; align-items: stretch; }
}